[right-post]Position-Specific Iterated BLAST (PSI-BLAST) is a user-friendly version of a profile-based search.BLAST does not always find all homologs because no search program is 100% sensitive. To find putative homologs that BLAST does not find, search with mathematical representation of the protein family. It is important to note that PSI-BLAST finds putative homologs. It is best to confirm the homology in the wet lab or in the dry lab.