in Personalized Medical Treatment[right-post]

naveenbioinformatics,bioinformatics jobs,bioinformatics phd

We’re excited about our work with the hospitals and research institutions using bioinformatics to achieve major healthcare breakthroughs and unlock the mysteries of the human body.This eBook highlights the important work bioinformatics organizations are undertaking and explains how we are helping them achieve their mission. The stories of these four organizations illustrate what is possible with the AWS Cloud:
  1. The National Institute of Health’s Human Microbiome Project (HMP) – Researchers from all over the globe can now access HMP data through Nephele, an AWS-supported platform, and use that information to identify possible microbial causes of preterm births, diabetes, inflammatory bowel syndrome, and other disorders.
  2. The INOVA Translational Medicine Institute (ITMI) – AWS architecture facilitates the storage and management of this secure data, and enables Inova researchers to develop personalized treatments and predictive care for newborns suffering from congenital disorders and patients of all ages with cancer-causing genetic mutations.
  3. University of California, San Diego’s  Center for Computational Biology & Bioinformatics (CCBB) – CCBB has seven core AWS-supported analysis pipelines, all optimized to handle next-generation sequencing data. Each pipeline is targeted at identifying small but important molecular differences, whether in a tumor’s DNA or in the microbiome, enabling doctors to tailor treatment on an individual level.
  4. GenomeNext – GenomeNext’s AWS based platform represents the newest technological benchmark in the history of genomic analysis, and allows even small research groups to complete genomic sequencing in a matter of hours at a fraction of the traditional cost.
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the future of healthcare[right-post]

[fquote]"Genetic engineering techniques are now cheap and widespread enough that any knowledgeable individual can order every material they need off the Internet and download the software to do experiments on themselves," said Raymond McCauley, Biotechnology and Bioinformatics Chair, Singularity University.[/fquote]
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[fquote]The PhD opportunity will be carried out at OncoImmunity resulting in a PhD awarded through the University of Oslo. The candidate will have academic mentors and supervisors at the University of Oslo, in addition to main supervisors in the OncoImmunity development and scientific team. This PhD position involves the research and development of novel machine learning algorithms to identify immunogenic mutations from patient genomes. The candidates background should be in machine-learning, big data and statistics. The ideal candidate will have a background in the analysis of cancer next generation sequencing (NGS) and research interests in developing novel methods that will allow for discoveries at the interplay between cancer and immunology, in order to identify improved personalized cancer immunotherapy.[/fquote]

Required experience 

  • We are looking for applicants who have an MSc degree in bioinformatics, statistics, computational biology, computer science, or applied mathematics.

Roles and responsibilities 

  • Apply machine-learning and statistical methods to NGS and associated proteomics information Excellent communication skills, and capable of providing clear visualization of data and results Experience in computer programming with strong familiarity with languages and technologies needed for statistical data analysis and machine-learning (Python, R, etc) Develop and implement pipelines for NGS data analysis Work closely in a scientific team developing a software solution, which relies on statistical analysis and machine-learning from next generation sequencing (NGS) of DNA. Work with other developers, the software development manager, CEO and the CSO, to develop key machine-learning and statistical methodology in the software solution. Passion to build an innovative software solution which will benefit cancer patients by empowering the development of ground-breaking immunotherapies. 


  • Cover letter CV Documentation of a relevant completed M.Sc. or equivalent degree. Course and grade list of bachelor and/or master degrees

[fquote]A three-year Ph.D. studentship in evolutionary biology is available in the laboratory of Andreas Wagner at the University of Zurich. We are looking for a researcher to study the origins of evolutionary innovations and phenotypic diversity in genetic systems, such as metabolic networks, regulatory circuits, and enzymes. Lab members are a group with very diverse backgrounds and research projects, unified by their interests in evolution and life’s fundamental organizational principles. Ongoing work in the lab ranges from the directed evolution of enzymes to laboratory evolution in E.coli and computational analyses of genetic networks (e.g., Hayden et al., Nature 2011; Payne and Wagner, Science 2014). A sample of the laboratory’s research can be found at [/fquote]

University of Zurich - Universität Zürich - UZH

  • The successful candidate will have a strong background in bioinformatics and computational biology. Fluency in a major scripting language such as perl, and experience in software development is a must. Also desirable is a strong background in biology. Applications without a demonstrated interest and research history in evolutionary biology will not be considered further. We are looking for an individual with a Masters Degree or equivalent, who is highly self-motivated and can work independently. 
  • The working language in the laboratory is English. German skills, although helpful, are not essential. Zurich is a highly attractive city in beautiful surroundings, with a multinational population, and many educational and recreational opportunities. 
  • To be considered, please send a single (!) PDF file merged from the following parts to [email protected]: CV including publication list, academic transcripts, a statement of research interests not exceeding three pages, and three academic references. Please include the word “PEVOLPHD16” in the subject line. Applications will be considered until April 22, 2016, or until the position is filled, whichever comes first. The position is available from the fall of 2016.

I can imagine a future where functional medicine is built into a bioinformatic system which analyzes your history, medical history, analyzes lab tests that can be done by yourself at a local pharmacy or anywhere or maybe a kit that’s sent to your home. That data gets put into a system. It’s driven through an artificial intelligence decision support system. It spits out guidelines and recommendations for you to do. You find other people to do it with in your community. 
[fquote]You learn how to actually connect the resources that are around you that link everything together. I mean, Uber didn’t invent anything new; it just linked together all sorts of resources to make things easy, and that can happen in medicine to help people change their lifestyle and behavior. It can link people in the community who want to get healthy together, who want to learn how to shop and cook and do all kinds of things.[/fquote]
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South by Southwest (SXSW) is right around the corner, so we created a Custom List in Mattermark to help you track them. We found 282 companies that will be represented at SXSW this year and below are the 23 fastest growing ones that are not public or acquired and have raised less than $100 million in funding. We used the Mattermark Growth Score to rank all 282 companies. The Custom List in Mattermark provides each company’s Growth Score, Mindshare Score, URL, location, total funding, all investors, employee count, employee count month-over-month change, current funding stage, location, estimated monthly uniques, and last funding date. Below are the top 23 on the list.
[fquote]Desktop Genetics (Mattermark Growth Score: 138) – A bioinformatics company, which develops technologies at the intersection of biotechnology, information management and laboratory automation.[/fquote]

It was a rallying call for investment in maths and physics research in Africa. The "Next Einstein" slogan became a mission for the organisation Neil Turok had founded to bring Africa into the global scientific community: the African Institute of Mathematical Sciences (AIMS). That search for an African Einstein now has some results, with 15 "Next Einstein Fellows" and 54 "Next Einstein Ambassadors" announced at an event last month. These are young African scientists, often leaders in their fields, working and studying in Africa.
[fquote]There are advantages in other fields, too. For scientists using bioinformatics to explore the origins of genetic disease, Africa holds a unique place as the cradle of humanity - and therefore the repository of our oldest genetic information.[/fquote] Read More

Think your DNA is all human? Think again. And a new discovery suggests it's even less human than scientists previously thought.Nineteen new pieces of non-human DNA -- left by viruses that first infected our ancestors hundreds of thousands of years ago -- have just been found, lurking between our own genes.
[fquote]The simple reason that software has bugs (that result in errors) is that writing software is hard.Let's take a simple example and say you want to write some software to determine if a genetic variant meets an autosomal recessive inheritance pattern. This is easy, right!? Just find sites where the affected parent is het, the unaffected is homozygous reference and the proband is heterozygous. Done. Too easy.[/fquote]
[accordion] [item title="£75M investment in bioinformatics"]UK Minister for Universities and Science David Willetts joined key stakeholders in the Cambridge biotechnology cluster today to celebrate the opening of a new Technical Hub for bioinformatics. The European Bioinformatics Institute's new South Building will be home to the ELIXIR Directorate, which will coordinate bioinformatics activities throughout Europe in order to increase the availability and uptake of biological data in commercial and non-commercial.Read More[/item] [item title="Scientists develop high-sensitivity software for searching massive DNA databases"]A new computer program was designed by Russian and American scientists and specialized for searching massive DNA databases for distant similarities, reports Institute for information transmission problems of the Russian Academy of Sciences (IITP RAS) press-service. Anna Kaznadzey, a junior researcher at IITP RAS took part in this work.Read More[/item] [item title="Teaching children how to be a sequence "]As part of a PhD it is anticipated1 that you will share your science with various audiences; fellow PhD students, peers in the field and the various publics. Every year, the university celebrates British Science Week with a Science Fair, inviting possibly the most difficult public to engage with: children. Over three days the fair serves to educate and entertain 1700 pupils from over 30 schools based across Mid Wales, and this year I volunteered2 to run a stand.Read More[/item] [item title="ISCB’s initial reaction to New England Journal of Medicine"]The recent editorial by Dr Longo and Dr Drazen in the New England Journal of Medicine (Longo and Drazen, 2016) has stirred up quite a bit of controversy. As Executive Officers of the International Society of Computational Biology, Inc. (ISCB), we express our deep concern about the restrictive and potentially damaging opinions voiced in this editorial, and while ISCB works to write a detailed response, we felt it necessary to promptly address the editorial with this reaction. Although some of the concerns voiced by the authors of the editorial are worth considering, large parts of the statement purport an obsolete view of hegemony over Read More[/item] [item title="Assistant Professor of Bioinformatics "]The Department of Molecular and Biomedical Sciences at the University of Maine is seeking to fill a tenure-track position at the Assistant Professor level in the area of Bioinformatics/Computational Biology. The successful applicant will establish and lead a productive research program in the areas of bioinformatics/computational biology that provides research opportunities for both undergraduate and graduate students. Specific research areas of interest for this position include but are not limited to genomics and systems biology including gene expression, evolution, population genetics, and microbiomics. Analysis of other datasets such as lipidomics, metabolomics, transcriptomics, epigenomics, etc. are also of interest. The Department of Molecular and Biomedical Sciences has an active research core in the areas of host-pathogen interactions, toxicology, and cell signaling, and an outstanding zebrafish facility that supports broad research areas. Other units on campus also offer areas for collaboration such as wildlife genomics, mouse models, and others. As a founding and active member of The University of Maine's Graduate School of Biomedical Sciences and Engineering, the reach and collaborations available to members of the Department extend to the physical and computational sciences and to institutions across the state of Maine, including the Mt. Desert Island Biological Laboratory, The Jackson Laboratory, and Maine Medical Center Research Institute. The department is actively developing a new Masters degree program in Bioinformatics and includes a phage genomics course in its undergraduate core curriculum. The applicant will teach within the Department of Molecular and Biomedical Sciences with emphasis on the development of new courses in computational biology at the advanced undergraduate and graduate level. The position is a 75% research/25% teaching position with a start date of January 1, 2017 or later.Read More[/item] [item title="Will Spark Power the Data behind Precision Medicine?"]The promise of precision medicine that President Obama envisions with this statement is a far-reaching goal that will require sweeping changes to the ways physicians treat patients, health data is collected, and global collaborative research is performed. Precision medicine typically describes an approach for treating and preventing disease that takes into account a patient’s individual variation in genes, lifestyle, and environment. Achieving this mission relies on the intersection of several technology innovations and a major restructuring of health data to focus on the genetic makeup of an individual. Read More[/item] [item title="Paper: “Undergraduate Bioinformatics Workshops Provide Perceived Skills”"]Bioinformatics is becoming an important part of undergraduate curriculum, but expertise and well-evaluated teaching materials may not be available on every campus. Here, a guest speaker was utilized to introduce bioinformatics and web-available exercises were adapted for student investigation. Students used web-based nucleotide comparison tools to examine the medical and evolutionary relevance of a unidentified genetic sequence. Based on pre- and post-workshop surveys, there were significant gains in the students understanding of bioinformatics, as well as their perceived skills in using bioinformatics tools. The relevance of bioinformatics to a student’s career seemed dependent on career aspirations.Read More[/item] [item title="More ancient viruses lurk in our DNA than we thought"]Think your DNA is all human? Think again. And a new discovery suggests it's even less human than scientists previously thought.Nineteen new pieces of non-human DNA -- left by viruses that first infected our ancestors hundreds of thousands of years ago -- have just been found, lurking between our own genes.Read More[/item] [item title=" What is the reason for most software errors in Bioinformatics "]The simple reason that software has bugs (that result in errors) is that writing software is hard.Let's take a simple example and say you want to write some software to determine if a genetic variant meets an autosomal recessive inheritance pattern. This is easy, right!? Just find sites where the affected parent is het, the unaffected is homozygous reference and the proband is heterozygous. Done. Too easy.Read More[/item] [item title="International Conference on Bioinformatics and Computational Biology (BICoB)"]In recent years, computational biology and medical informatics have seen significant advances driven by computational techniques in bioinformatics making bioinformatics and computational biology among the most vibrant research areas. The 7th international conference on Bioinformatics and Computational Biology (BICoB-2016) provides an excellent venue for researchers and practitioners in the fields of bioinformatics and computational biology to present and publish their research results and techniques. The BICoB conference seeks original and high quality papers in the fields of bioinformatics, computational biology, systems biology, medical informatics and the related disciplines.Read More[/item] [item title="The 100 Best Bioinformatics(Computer Science) Programs in the World"]At Princeton, one can research problems in Bitcoin and Crypto currencies, bioinformatics, computational neuroscience, geo-replicated cloud storage and any number of other leading subfields of information theory. Not surprisingly given Princeton’s focus, all its students, even undergraduates, are required to do at least one design or research-related project before graduation.Read More[/item] [item title="Software Architecture Training Conference in La Jolla"]creating applications for bioinformatics, finance, and retail. To make byte code more accessible, he created the open-source Java Assembler Kit (JAK) which provides a fluent API for producing Java byte code and includes a REPL to allow for interactive experimentation.Read More[/item] [item title="Wellcome Trust and COAF Open Access Spend, 2014-15"]Once a year we ask all those institutions in receipt of an open access (OA) grant from the Trust to provide details on how the grant has been spent. In 2014 six research funders established the Charity Open Access Fund (COAF) in order to provide a single funding mechanism to cover Article Processing Charges (APCs). The data supplied by institutions for the 2014-15 report therefore covers APC spend on articles arising from research funded by Arthritis Research UK, Breast Cancer Now, Bloodwise, British Heart Foundation, Cancer Research UK and the Wellcome Trust.Read More[/item] [item title="A new approach to sequence and assemble primate genomes"]A new sequencing technology based on longer sequence reads allows missing genes and missing forms of genetic variation to be discovered for the first time. This assembly offers new biological insights into a living species that is second only to chimps in its evolutionary closeness to humans.Read More[/item] [item title="Science relies on computer modelling"]From the transforming discovery of penicillin to the theories of relativity and quantum mechanics, science progressed with mind-boggling speed even before there were computers. Much of this is down to the robustness of the scientific method: scientific results are validated by being replicated and extended by other scientists.Read More[/item] [item title="MOOC Course Report: April 2016"]A big welcome to “Bioinformatics: Introduction and Methods” from Peking University! In this MOOC you will become familiar with the concepts and computational methods in the exciting interdisciplinary field of bioinformatics and their applications in biology, the knowledge and skills in bioinformatics you acquired will help you in your future study and research.Read More[/item] [item title="Roche and Discuva in superdrug partnership"]The two companies announced on 28 February that they have entered a collaboration and licence agreement for the discovery and the development of antibiotics. The drugs are to treat infections caused by multi-drug resistant Gram-negative bacteria using Discuva’s Selective Antibiotic Target IdentificatioN (SATIN) technology. This next-generation sequencing and bioinformatics platform will be used to identify bacteria and select promising drug candidates.Read More[/item] [item title="Sample size calculation while controlling false discovery "]RNA-Sequencing (RNA-seq) experiments have been popularly applied to transcriptome studies in recent years. Such experiments are still relatively costly. As a result, RNA-seq experiments often employ a small number of replicates. Power analysis and sample size calculation are challenging in the context of differential expression analysis with RNA-seq data. One challenge is that there are no closed-form formulae to calculate power for the popularly applied tests for differential expression analysis. In addition, false discovery rate (FDR), instead of family-wise type I error rate, is controlled for the multiple testing error in RNA-seq data analysis. So far, there are very few proposals on sample size calculation for RNA-seq experiments.Read More[/item] [item title="24 phenomenal founders crashing the tech party"]A mathematician with a PhD in molecular evolution and bioinformatics, Nora Khaldi founded Nuritas in 2014 to ‘make the future of food’. Combining AI and DNA sequencing, Khaldi’s pioneering approach to bioinformatics has seen the company revolutionise how we study food. Khaldi will be speaking at Inspirefest this summer.Read More[/item] [/accordion]

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