The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.
Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.
The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.
- The new Centre for Evolution and Cancer within the ICR is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future. In particular, we are interested in the dynamics of cancer clone development in patients and the impact of therapy. We also aim at integrating our newly generated data with existing large-scale genomic datasets to delineate evolutionary trajectories in large cohorts, with the goal of developing novel evolutionary biomarkers that have predictive and prognostic value. For more information please visit http://www.icr.ac.uk/our-research/our-research-centres/centre-for-evolution-and-cancer and http://www.icr.ac.uk/news-features/latest-features/the-centre-for-evolution-and-cancer.
- Our six teams have a strong international track record in applying the principles of evolutionary biology to cancer. We work closely with the ICR’s Tumour Profiling Unit for the genomic profiling and collaborate extensively with other scientists in the ICR, oncologists in the Royal Marsden NHS Foundation Trust as well as with an international network of colleagues in the field of cancer evolutionary biology. For more information please visit http://www.icr.ac.uk/Media/centres-and-initiatives/cec-prospectus-updated-january-2015.pdf?sfvrsn=2.
We seek two talented bioinformatics scientists to join the newly established Bioinformatics group. The appointed individuals will lead the development of computational pipelines for the analysis of cancer genomics data with particular focus on next-generation sequencing data (DNA-seq, RNA-seq, ChIP-seq, etc). The two bioinformaticians will also be involved in the development of novel tools for cancer evolution analysis. They will also be engaged in collaborative research projects within the Centre and beyond, potentially resulting in high profile publications. They will be encouraged to develop their own research interests in areas related to the Centre's activities.
- Informal enquiries about these posts (including arrangements to visit the ICR/Centre) are welcome and may be directed to Dr Stefano Lise, Head Bioinformatician designate, by email: [email protected].
- To apply please submit your CV and covering letter (addressing where you meet the person specification, and incl. the names and addresses of two referees) online.
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