New kinase inhibition full matrix dataset
We've just processed and integrated a new full matrix kinase inhibition dataset, kindly provided by EMD Millipore. As described in this recent paper, it covers 234
human wildtype kinases and kinase complexes, as well as 158 'standard'
kinase inhibitors tested at two concentrations, leading to more than
73,000 data points. Analysis of the data could provide new insights to
kinase selectivity/promiscuity/polypharmacology (depends on how you look
at it) and their relationship with chemical structure. The dataset will
be available with ChEMBL_16 next month.
PS: The
image above shows the activity profile of four kinase inhibitors across
the human kinome families from the Millipore data. It was produced with
circos by Rita.
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