GPCRs heterodimerization appears to play a role in modulating agonist/antagonist affinity, efficacy and/or trafficking properties, the molecular models of GPCRs required to understand receptor function must consider these oligomerization hypotheses. To advance knowledge in this field, we would like to investigate the role of heterodimer GPCRs receptor inside the lipid-bilayer and also we would like to study GPCRs-ligand interactions through computational approach. Thereby we would like to explore the pharmaceutical potential of GPCR heterodimers for therapeutic intervention in HIV1 infection and in Cancer.
Detailed Description
Prepare a first draft with an in-depth analysis of the materials needed to complete the PhD subject
Carry out his/her PhD in accordance with the conditions agreed between the university and the laboratory (e.g. PhD charter defining the work relationship between the student and the supervisor)
Work with a researcher who has set up a research project and participate in the drafting of scientific articles about the ongoing project
Develop a scientific methodology and techniques adapted to the research project
Present the work as well as results during laboratory meetings and at international scientific meetings
Communicate problems and suggestions for possible solutions in a clear way
Publish in peer-reviewed international journals
Main professional relations:
Functional reporting line: project leader or researcher
Internal: project leader, members of the project team
External: dealing with external professional contacts as defined in his/her research projects
Job Requirements
Obligations:
The candidate will apply for a PhD at the Luxembourg Institute of Health with an AFR grant (research training aid from the Fonds National de la Recherche, Luxembourg) and will start his/her fixed-term employment contract for 3 years after acceptation of the grant by the FNR
Strictly follow the organizational procedures set up by the CRP-Santé
Respect the confidentiality of the data
Adapt working hours to project requirements
Specificity:
The PhD student must receive an AFR (research training aid) to complete his/her PhD
The candidate may be a student (for the whole PhD cycle)
Possibilities to travel abroad to learn new techniques
Additional Details
Master degree (or equivalent) in Bioinformatics or system biology or related disciplines
Experience in MD simulation, Molecular docking or molecular modelling related to G protein-coupled receptors is a plus
Knowledge in programming and Linux scripting are necessary
Rigor, motivation, scientific creativity and originality, writing skills, conciseness, sense of priority and sense of human relations
The candidate should be fluent in spoken and written English; preference will be given to applicants with good publication records in relevant areas
GPCRs heterodimerization appears to play a role in modulating agonist/antagonist affinity, efficacy and/or trafficking properties, the molecular models of GPCRs required to understand receptor function must consider these oligomerization hypotheses.
