FIRST META CENTER SYMPOSIUM ON HOST-MICROBE SYSTEMS BIOLOGY

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The first META Center Symposium on Host-Microbe Systems Biology, held in Eugene last weekend, brought together scientists from diverse disciplines for a stimulating weekend of presentations and discussions. The symposium kicked off on Friday evening with a fascinating talk by Curtis Huttenhower entitled “Known knowns and known unknowns in host-associated microbial communities,” that drew parallels between the development of microarray technology and the current emerging field of microbiome research.
  • Six scientific sessions on Saturday and Sunday featured talks from world leaders in fields including microbial ecology, infectious disease, computational biology, and population genetics. Participants were riveted by David Schneider’s presentation on modeling the dynamics of host responses to pathogen infection, with clear potential applications to many host-commensal systems.
  • Elhanan Borenstein offered another example of modeling host-associated microbial communities that used constraint based metabolic models for individual members to predict emergent biosynthetic capacities. Several presenters, including Angela Douglas and Andrew Clark, offered approaches to defining the host genetic factors that influence microbial community assembly. Others, including Larry Forney, Katie Pollard, and Ned Wingreen, showed how analysis of temporal human microbiome data could provide insights into community dynamics.
  • Andrew Goodman and Eugene Chang used elegant gnotobiotic experiments to reveal the functions of bacterial traits (defenses against antimicrobial peptides) or host processes (circadian cycles) in maintaining healthy host-microbe systems. Participants were wowed by Hyun Jung Kim’s microengineered human gut on a chip in which Caco2 cells, when cultured in microfluidic devices and subjected to forces and flows mimicking peristalsis, elaborated villar structures that could be maintained with mixed communities of probiotic bacteria.
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Kicking off the 2014 META symposium- Nancy Hamren (Springfield Creamery), Karen Guillemin (University of Oregon, META Center Director), and Judith Eisen (University of Oregon)

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The first META Center Symposium on Host-Microbe Systems Biology, held in Eugene last weekend, brought together scientists from diverse disciplines for a stimulating weekend of presentations and discussions.