The bestselling introduction to bioinformatics and genomics

Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

• Extensive revisions and a slight reorder of chapters for a more effective organization
• A brand new chapter on next-generation sequencing
• An expanded companion website, also updated as and when new information becomes available
• Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities

The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Table of Contents

Part I Analyzing DNA RNA and Protein Sequences

• Introduction 3
• Access to Sequence Data and Related Information 19
• Pairwise Sequence Alignment 69
• Basic Local Alignment Search Tool (BLAST) 121
• Advanced Database Searching 167
• Multiple Sequence Alignment 205
• Molecular Phylogeny and Evolution 245

Part II Genomewide Analysis of DNA RNA and Protein

• DNA: The Eukaryotic Chromosome 307
• Analysis of Next-Generation Sequence Data 377
• Bioinformatic Approaches to Ribonucleic Acid (RNA) 433
• Gene Expression: Microarray and RNA-seq Data Analysis 479
• Protein Analysis and Proteomics 539
• Protein Structure 589
• Functional Genomics 635

Part III Genome Analysis

• Genomes Across the Tree of Life 699
• Completed Genomes: Viruses 755
• Completed Genomes: Bacteria and Archaea 797
• Eukaryotic Genomes: Fungi 847
• Eukaryotic Genomes: From Parasites to Primates 887
• Human Genome 957
• Human Disease 1011

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