Bioinformatics Quiz:

Test Your Knowledge of Bioinformatics[right-post]

[fquote]Every year Department of Biotechnology  conduct a DBT-JRF BET examination  for BIOTECHNOLOGY and BIOINFORMATICS students,if you consider both part A and Part B then there is  ~15 to 20 questions which are asked from BIOINFORMATICS,because this year BINC(BINC-2016) is also going to conduct in which BIOINFORMATICS play major role;so for these reasons i have decided to consider all BIOINFORMATICS questions,which was asked in DBT-JRF  (2008-2014) Question papers.For that i have prepared "BIOINFORMATICS QUIZ" which not only help you to do good score in  DBT-JRF BET-2016 but it is also useful in BINC-2016(part A MCQs).I have selected All these questions from DBT-JRF  (2008-2014)Question papers;which are available on DBT Website (http://dbtindia.nic.in/uniquepage.asp?id_pk=16)[/fquote]

 Points to Remember :

1. Option which is given in BOLD RED colour is an answer of that question.
2. If you find out any doubt for particular question or you think that answer which is given is not right; please cross check it with DBT Website (http://dbtindia.nic.in/uniquepage.asp?id_pk=16)or you can inform me on my email: [email protected]
3. please send me complete question including all four options and also consider in which option you have doubt and according to you which option should be right and why????....Thanks .

Bioinformatics Quiz: Test Your Knowledge of Bioinformatics

[lock][/lock]

syllabus of Bioinformatics in DBT-JRF BET examination

1. Major Bioinformatics Resources:

• Sequence databases, Gene Expression database: GEO, SAGE, 3D Structure Database: PDB, NDB, Knowledge driven Databases & utility, Pattern Sequence: InterPro, Prosite, Pfam, ProDom, Gene Ontology

2. Database Searches:

• Keyword-based searches using tools like ENTREZ and SRS Sequence-based searches: BLAST and FASTA

3. Sequence Analysis, Basic concepts:

• Sequence similarity, identity and similarity, definitions of homologues, orthologues, paralogues, Tandem and Interspersed repeats, repeat finding.

4. Scoring Matrix,

• Pairwise sequence alignments, Multiple sequence alignments (MSA), Application in Taxonomy and phylogeny, Comparative genomics.

5. Structural Biology:

• 3-D structure visualization and simulation, Basic concepts in molecular modeling: different types of computer representations of molecules. External coordinates and Internal Coordinates, Molecular Mechanics, Force fields
  etc.

6. Proteins:

• Secondary structure elucidation using Peptide bond, phi, psi and chi torsion angles, Ramachandran map, anatomy of proteins – Hierarchical 12organization of protein structure –like CATH,SCOP, FSSP .

7. DNA & RNA secondary and tertiary structures, t-RNA tertiary structure

8. Classification and comparison of protein 3D structures:

• Secondary structure prediction: Algorithms viz. Chou Fasman, GOR methods,
• Tertiary Structure prediction: Fundamentals of the methods for 3D structure prediction (sequence
  similarity/identity of target proteins of known structure, fundamental principles of protein folding etc.
• Homology/comparative Modeling, fold recognition, threading approaches, and ab initio structure prediction methods. CASP. Computational design of Promoters, Proteins & Enzymes.

9. Application in drug design:

• Chemical databases like NCI /PUBCHEM. Fundamentals of Receptor-ligand interactions.
• Structure-based drug design: Identification and Analysis of Binding sites and virtual screening
• Ligand based drug design: Structure Activity Relationship – QSARs & Pharmacophore etc. In silico predictions of drug activity and ADMET.